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Your Comprehensive Guide to Semaglutide

It was the summer of Semaglutide; in the media, medical offices and all over Hollywood and the fall continuing to buzz as people see the remarkable results from these popular weight loss drugs. So, is it worth the hype? You may have heard of Semaglutide under the brand names Ozempic and Wegovy, so let’s unravel the science behind this popular peptide. 

The Science Behind Semaglutide

Semaglutide is a GLP-1 agonist, which stands for Glucagon Like Peptide 1. This peptide is naturally produced in our gut and serves a vital role in regulating our body’s insulin response and insulin sensitivity, ultimately leading to lower blood sugar levels. It’s a key player in the delicate balance of our metabolic health.

Initially approved by the FDA in 2017 for diabetes management, Semaglutide made headlines again in 2021 when it earned the green light as Wegovy, a groundbreaking treatment for obesity without diabetes. But what’s the secret behind its dual action on blood sugar and weight?

The Weight-Loss Magic of Semaglutide

While we’re still uncovering all the mysteries of Semaglutide, two key mechanisms have captured our attention:

  • Central Action on the Brain: Semaglutide works its magic centrally, in the brain. By acting as a GLP-1 agonist, it helps reduce hunger and suppress appetite. Think of it as turning down the volume on the constant “food noise” in your mind. This can be a game-changer, especially for those who battle emotional and genetic factors contributing to weight gain. Quieting that noise allows you to reconnect with your body’s hunger and satisfaction cues, a liberating experience for many.
  • Local Effects on the GI System: Semaglutide doesn’t stop at the brain; it also influences your gastrointestinal system. By slowing down the transit of food through your digestive tract, it ensures that food lingers in your stomach longer, making you feel full sooner and for an extended period.

The synergy of these central and local effects leads to weight loss and improved glycemic control, helping you achieve your health goals.

Are Semaglutide Right for You? 

This once-weekly injectable medication can be administered conveniently at home or in our office, depending on your preference. Our approach is to start low and advance slowly, tailoring the dosing to your unique needs. The goal? Achieve your desired weight with minimal side effects.

Maintaining Your Weight Loss

The million-dollar question: “Will I regain the weight after stopping Semaglutide?” Well, it’s a possibility, but not all hope is lost. Data from Semaglutide trials show that some patients did regain weight post-treatment, but they never returned to their pre-Semaglutide weight.

Our mission is to help you find your body’s “set point,” a weight that feels optimal and healthy for you, as this varies based on your genetics. As you get closer to your set point, weight loss might slow down.

Here’s where the functional medicine difference shines. At Blum Center for Health, your journey with Semaglutide is just the beginning. We embark on a 12-week exploration to uncover the root causes of your weight gain. We dive deep into intensive testing for blood work abnormalities, hormone imbalances, toxic load, nutrient deficiencies, and dysbiosis, among other factors. Our dedicated health coaching supports you in correcting these imbalances, ensuring that your weight loss is not just temporary but lasting.

Semaglutide is a groundbreaking tool, offering hope for those seeking to manage diabetes, combat obesity, and achieve lasting weight loss. Our approach goes beyond the prescription, addressing the root causes of weight gain and empowering you to maintain your newfound vitality.

Macaulay and Melissa will be with you every step of the way. Are you ready to embark on your journey to better health with Semaglutide? Book an appointment by calling 914.652.7800 or visiting

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